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Color changing polymer to signal traumatic brain injuries , polymer gel for swallowable devices with ultra-long drug delivery

Color changing polymer to signal traumatic brain injuries , polymer gel for swallowable devices with ultra-long drug delivery

29-Sep-15

Some of the head injuries caused by a bomb blast or a rough tackle can inflict brain damage that destroys lives. Soldiers and professional athletes often suffer traumatic brain injuries (TBIs) due to severe impacts. Rapid detection of TBIs can be challenging, since trauma to the head is not visually detectible without the aid of complex medical equipment found in a hospital setting. To detect head trauma immediately, a team of researchers from the University of Pennsylvania has developed a polymer-based material that changes colors depending on how hard it is hit. The goal is to someday incorporate this material into protective headgear, providing an obvious indication of injury. Although still in the proof-of-principle stage, this technology is intended for use in helmets as a visual indicator of severe impact and underlying head trauma. Timely diagnosis is critical for the effective treatment of TBIs and the prevention of cumulative brain damage. Recent research and media accounts have indicated that soldiers and professional athletes may suffer long-term complications - such as memory loss, headaches and dementia - stemming from past head trauma. But a force-responsive, color-changing patch could prevent additional injury, says Shu Yang, Ph.D. "If the force was large enough, and you could easily tell that, then you could immediately seek medical attention," she explains.
Yang's team at the University of Pennsylvania used holographic lithography (HL) to create photonic crystals with carefully designed structures to give them a particular color, just like opals. Deforming the crystals with an applied force changes their internal structures, and thus the crystal's color. The material does not require power to detect forces and is lightweight, thus offering an attractive way for medical personnel to identify a damaging force on-site without the use of expensive tools. However, making these crystals is an expensive process that isn't suitable for the mass production, she says. So the team turned to self-assembly and polymer-based materials that are cheaper to produce over a large area than the earlier HL method. Younghyun Cho, Ph.D., a p
The first step was to mold the polymer into a structure that worked just like the specialized photonic crystals. To make a mold, the researchers mixed up silica particles of various sizes and allowed them to self-assemble into crystals with the desired pattern. They heated the polymer, which infiltrated the mold, allowed it to solidify and then removed the silica mold, leaving behind the inversed polymer crystals. The researchers then applied varying amounts of force to the polymer crystal and recorded the color change. The results were encouraging. "We were able to change the color consistently with certain forces," Yang says. For example, applying a 30 mN force - approximately the force of a sedan moving at 80 miles per hour crashing into a brick wall-caused the crystal to change from red to green. A force of 90 mN - the equivalent of a speeding truck hitting that same wall-turned the polymer purple, Cho adds. "This force is right in the range of a blast injury or a concussion," Yang says. In future studies, Yang plans to develop materials that can indicate how quickly a force is applied, which affects how damaging a particular trauma is on the brain.

A new polymer gel could help create swallowable devices for ultra-long drug delivery. Medical devices designed to reside in the stomach have a variety of applications, including prolonged drug delivery, electronic monitoring, and weight-loss intervention. However, these devices, often created with nondegradable elastic polymers, bear an inherent risk of intestinal obstruction as a result of accidental fracture or migration. As such, they are usually designed to remain in the stomach for a limited time. Researchers at MIT's Koch Institute for Integrative Cancer Research and Massachusetts General Hospital (MGH) have created a polymer gel that overcomes this safety concern and could allow for the development of long-acting devices that reside in the stomach, including orally delivered capsules that can release drugs over a number of days, weeks, or potentially months following a single administration. This polymer is pH-responsive: It is stable in the acidic stomach environment but dissolves in the small intestine's near-neutral pH, allowing for safe passage through the remainder of the gastrointestinal (GI) tract. The material is also elastic, allowing for the compression and folding of devices into easily ingestible capsules - meaning this polymer can be used to create safe devices designed for extremely prolonged residence in the stomach. "One of the issues with any device in the GI tract is that there's the potential for an obstruction, which is a medical emergency potentially requiring surgical intervention," says Koch Institute research affiliate Giovanni Traverso, also a gastroenterologist at MGH and an instructor at Harvard Medical School. "A material like this represents a real advance because it is both safe and stable in the stomach environment." Designing devices for the stomach is a complicated matter of sizes and shapes. The stomach naturally empties its contents in a matter of hours, so for devices to be retained, they must be wider than the pylorus - the valve at the end of the stomach, about 1.5 to 2 centimeters in diameter, that allows gastric contents to pass into the small intestine. However, because the most convenient path to deliver these devices is through the esophagus, which is only marginally wider than the pylorus, the researchers were interested in developing a polymer with elastic properties. "An elastic device can be folded into something small, such as a capsule, and be easily ingested through the esophagus before expanding in the stomach, restoring its original shape," Zhang says. "When you have a device that's larger than the pylorus, there's a much higher probability that it will be retained longer in the stomach." But the size and shape of existing devices with elastic polymers have been limited by safety concerns, as there is a greater risk for fracture if a device is too large or too complex. Because of this, the researchers wanted their polymer to also be enteric- or have a mechanism that would enable it to pass through the stomach unaltered before disintegrating in the intestines."To lower any possible risk of obstruction, we wanted a material that could dissolve in the intestines, thereby dissociating the device, and safely pass out of the body," Zhang says.
To create this new material, the researchers synthesized an elastic polymer and combined it in solution with a clinically utilized enteric polymer. Adding hydrochloric acid and centrifuging the solution resulted in a flexible, yet resilient, polymer gel that exhibits both elastic and enteric properties. The researchers used the gel polycaprolactone (PCL), a nontoxic, degradable polyester, to construct several device prototypes. They first created ring-shaped devices by using the gel to link arcs of PCL in a circular mold. These elastic devices had a diameter of 3 centimeters - wider than the pylorus - before they were folded into orally ingestible capsules. In testing the capsules in pigs, the researchers found that the rings expanded into their original shape within 15 minutes of ingestion and remained in the stomach for up to seven days. After the device passed out of the stomach, the polymer gel dissolved, allowing for the safe passage of the small PCL pieces without obstruction. The researchers also created larger devices in various shapes that could be folded and delivered through the esophagus with the assistance of an endoscope. These devices remained in the stomach for up to five days, after which the gel similarly dissolved, allowing for the remnants of the device to safely pass. The combined enteric and elastic properties of this polymer gel could significantly improve the design and adoption of gastric-resident devices. Devices that could incorporate this material include bariatric devices for the treatment of obesity, which control how hungry or full a person feels; ingestible electronics, which can diagnose and monitor a variety of conditions in the GI tract; or extended-release drug-delivery systems that could last for weeks or months after a single administration. In particular, the authors say they are excited for the drug-delivery applications of this technology. With further work in adjusting the polymer composition or the design of the system, they say that they could tailor devices to release drugs over a specific timeframe of up to weeks or months at a time. MIT is negotiating an exclusive license agreement with Lyndra, an early-stage biotechnology company developing novel oral drug-delivery systems.
Such single-administration events could improve medication adherence, which remains a major clinical barrier. According to the World Health Organization, patients' adherence to long-term therapies for chronic illnesses is only 50% in developed countries, with lower rates of adherence in developing nations. Medication nonadherence costs the U.S. an estimated US$100 billion every year, the bulk of which comes in the form of unnecessary hospitalizations. The researchers also say that single-administration delivery systems for the radical treatment of malaria and other infections could significantly benefit from these technologies. In a March 2015 commentary piece in Nature, Traverso and Langer wrote that the GI tract is an area rife with opportunity for prolonged drug delivery in tackling this global health problem. With this new material, which can be used to create extended-release systems via swallowable "pills," they envision an emerging field of orally delivered devices that can maximize adherence and therapeutic efficacy.

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