| A range of polymer coatings are available in  the form of lubrications, anti-microbial liquids, water repellent polymers.  Each variant is used for different  applications. Besides sanitation, the other concerns about coatings are allergenic  substances, risk of new infections, FDA  compatibility standards, resistance to microbe absorption and transference. Research  has seen developments in coatings to enhance performance of devices. 
 For many types of implants, including stents,  endotracheal tubes, urinary catheters and vascular grafts, there is a risk  of infection. Some present issues with blood clotting as well. Infections from  medical implants can pose major problems to public health. Dr. Hitesh Handa, an  assistant professor at the University of Georgia in the School of  Chemical, Materials, and Biomedical Engineering and his team are developing  polymer coatings for medical implants to reduce health risks. These coatings  help prevent growth of bacteria clusters, called biofilm, which can form on  medical implants and lead to infection. This work involves a lot of different  people including collaborators in Michigan, some UGA students and the  Veterinary School at UGA.
 The my group is trying to develop coatings  that can release nitric oxide gas, which can mimic what the body does to  prevent clotting and infection. Nitric oxide is a gas that is produced in the  human body. The gas is released by the veins and arteries in order to prevent  platelet activation, which helps prevent blood clotting. Nitric oxide is also  released in the sinuses and by white blood cells to fight harmful bacteria. Handa  said by “minimally hurting” animals, the research team will be able to find out  if the medical coatings are really working.
 A timeline for when people can expect to have  access to these type of treatments on a large scale is largely an estimation at  this point.
 Australian scientists have developed a polymer  coating that can test for bladder cancer more simply and much cheaper than  current invasive techniques. Professor Krasi Vasilev, from the University of  South Australia's Future Industries Institute, told Plastics News  that his team was researching antibiotic properties of  polyoxazoline-based polymers and discovered a polymeric compound that will bind  to cancer-specific antibodies in urine. That enabled the researchers to develop  a portable, non-invasive devise to test for bladder cancer. Vasilev said  bladder cancer is difficult to diagnose and the probability of recurrence is  high — about 75% within five years. Survivors have regular cytoscopies, which  involve inserting a thin tube with a camera attached through the urethra to the  bladder. This is a very invasive procedure, is expensive, requires  hospitalization and can lead to complications. The new test exposes a urine  sample to a 20-nanometer-thick polymer coating on a substrate. The compound  binds to antibodies when it recognizes a protein on the surface of cancer cell  membranes. The device uses biosensors and micro-optics to identify the presence  of those cells.
 The research is led by Adelaide, South  Australian-based SMR Technologies, a unit of SMR Automotive Australia Pty. Ltd.  Vasilev said the polyoxazoline-based polymer technology, which has been  patented, has potential for other medical uses. Its antibacterial properties  may be useful for implantable devices. Valisev said almost half of  hospital-based infections occur after medical devices, like artificial knees  and hips, are implanted.
 Infections caused by bacterial colonization of  medical devices are a substantial problem for patients and the health-care  industry but the polyoxazoline coatings are a potential solution. Vasilev is  also researching ways to use them in antifouling applications for ships. He  said "undesirable biological adhesion" also has detrimental effects  in food processing and a wide range of other industries. Using plasma  polymerization to form nanoscale coatings on a solid substrate means no prior  substrate preparation is required and eliminates use of organic solvents  "so it's a greener technology," Vasilev said.
 A team is working  to reduce infections with a smart polymer that changes color and activates  natural antimicrobial enzymes when bacterial contamination is detected.Constant exposure  to salivary bacteria makes dental tools, such as reusable X-ray imaging plates,  ideal environments for virulent biofilms. Associate Professor Niveen Khashab,  her Ph.D. student Shahad Alsaiari and colleagues from the University's Advanced  Membranes and Porous Materials Center realized that switching to gold  nanoparticles could give antimicrobial coatings detection capabilities—these  tiny crystals have sensitive optical properties that can be tuned to spot  specific biomolecular interactions. But incorporating them safely into polymers  required new types of nanofillers.
 The team's approach  uses gold nano clusters treated  with lysozyme enzymes that have innate defenses against pathogens, such as  Escherichia coli, commonly known as E. coli. They attached these colloids to  the surface of slightly larger, porous silica nanoparticles stuffed with  antibiotic drug molecules. Normally, this gold-silica complex emits glowing, red  fluorescent light. But when the lysozyme units encounter bacteria, a strong  attraction for cell walls rips the gold nanoclusters from their silica  partners—an action that simultaneously switches off fluorescence and releases  the antibiotic cargo.
 Blending  experiments revealed the gold-based nanofillers integrated thoroughly into  polymer composites and exhibited minimal leaching during trials with E. coli.  Khashab attributes these favorable polymer interactions to the sharp exposed  edges of gold clusters on the silica spheres. The researchers tested their  concept by comparing X-ray dental plates with and without the smart polymer coating. Both samples yielded the same  high-resolution images of teeth and bone structure. However, only the coated  plate enabled rapid visual assessment of bacterial contamination, simply by  illuminating the device with a UV-lamp and looking for color change. Successful  release of the antibacterial agent also drastically decreased biofilm buildup.
 
 
 | 
{{comment.DateTimeStampDisplay}}
{{comment.Comments}}