| Polymers of microbe origin, 
                                  or biopolymers, have recently drawn increasing 
                                  attention of specialists. Biopolymers that are 
                                  auto destructible after some time have been 
                                  developed by Russian researchers. Obtained with 
                                  the help of bacteria, they are ideally suited 
                                  for healthcare. These polymers have two important 
                                  advantages. Firstly, they get destroyed in the 
                                  environment and thus solve the problem of contamination. 
                                  Secondly, being biocompatible they are not rejected 
                                  by an organism when applied for medical purposes. 
                                 These are polymers of ox derivative fatty acids, 
                                  the so-called polyhydroxyalkanoates (PHAs). 
                                  Some microorganisms, for example, hydrogen bacteria 
                                  that get vital energy via oxidizing hydrogen, 
                                  are able to synthesize PHAs. PHAs have a lot 
                                  of advantages - their physicochemical characteristics, 
                                  thermoplasticity, is the same as that of polypropylene 
                                  and polyethylene, and they possess antioxidant 
                                  and optical properties and piezoelectric effect. 
                                  Besides, like any biopolymers, they are compatible 
                                  with tissues of organism and get destroyed in 
                                  the environment. That is why their application 
                                  is promising for use in medicine (surgical and 
                                  disposable materials), pharmacology (prolongation 
                                  of drug action), food industry (packing and 
                                  antioxidant materials), agriculture (destructible 
                                  films).  Researchers first tested the polymer production 
                                  technology in the laboratory and then in production 
                                  environment. So far, the scientists can obtain 
                                  three types of polymers: polyoxybutyrate and 
                                  its copolymers with oxybutyrate and oxyvalerianate, 
                                  but in the future the range of goods will increase. 
                                  Within a week, 1 kilogram of polymer (or upto 
                                  50 kilograms pa) can be produced on the installation. 
                                  It is interesting to note that various articles 
                                  need absolutely different rate of polymer biodegradation 
                                  - suture threads and films should dissolve quickly, 
                                  but stents and valve prostheses should serve 
                                  for a long time. This is achieved by changing 
                                  the degradation rate that depends on the surface 
                                  type. Degradation rate can vary if different 
                                  fillings are used, or it can be accelerated 
                                  when needed through preliminary gamma irradiation. 
                                  The researchers are mainly interested in PHA 
                                  utilization for medical articles. Wound healing 
                                  films, suture material, covering for vessel 
                                  prostheses (stents), matrix for bioartificial 
                                  organs and implantates, membranes, microparticles, 
                                  etc from bio polymers are under production currently.
 Biopolymers underwent tests on animals at the 
                                  Scientific Research Institute of Transplantology 
                                  and Bioartificial Organs (Ministry of Health 
                                  of the Russian Federation). Trade mark of biomaterial 
                                  - ElastoPOBtm - has been registered and clinical 
                                  trials have been started. As per specialists, 
                                  the current demand for polymers for medicine 
                                  stands at 400,000 tons pa, therefore industrial 
                                  production of destructible bioplastics is considered 
                                  economically feasible. Based on the polymer's 
                                  sale price of 95 rubles per kilogram, they have 
                                  already calculated polymer's pay-back, return 
                                  and profitability.
 |